Welcome to the wise and wonderful world of being a curmudgeon. It's ok many of us stayed in the closet for years, but at some point, you just gotta embrace your inner angry old person and let it out.
Ok... Mostly joking... Mostly...
I've been a curmudgeon for a long time now. I have expressed open disdain and disappointment with/for lol cats for as long as that's been a thing.
The two methods I find most successful in stopping the rising meme tide; are as you mentioned one-word responses, and finding my own darker and slightly off putting memes.
The one-word responses thing simply needs to feel like a very subtle mix of indifference and being very slightly patronizing. It's as simple as replacing "haha" with
It's a cultivated skill to use these, so tread slowly and carefully. People will accuse you of being an inhuman monster for not liking puppies in a kiddie pool. You gotta ease into it.
The other method is a little more advanced, but it can be fun with the right sort of people. Find memes that express how you feel about the meme or video presented. If it's indifference that's heavily covered and easy to find, as are irritation, and simple mockery. I'd share a few of mine, but I'm pretty sure they would violate the "be nice" policy.
Be warned retaliatory memes are for people who can roll with cynical, sarcastic, and dark. If your people are easily upset, I would ease into the indifferent one-word responses.