我們可以"人群解決"的輸入數據集是否存在與COVID-19(冠狀病毒)相關的優化問題?


42

有人知道藥物/疫苗相關的挑戰具有良好的問題定義和一些可用的輸入數據集,理想情況下與COVID-19相關嗎?那將是什麼樣的約束解決挑戰?Protein folding?

如果存在任何此類約束解決問題,我們可以將其放在GitHub中,也許可以在社區中人群解決它​​們。如果公共生活像在中國和意大利北部那樣有限,那麼無論如何我們都會有很多時間:)

更新

當前的主要目標是找到 COVID-19蛋白折疊的可靠問題定義。迄今為止最有希望的參考文獻:

如果您正在調查其中的任何一個以查找問題定義,請在下面添加註釋。同時用您的結果編輯該問題。

其他用例

10

I was thinking of ( no data but):

  • determining which airline routes to block that will minimize the economic consequences given a very low risk of getting to the virus (like a chance constraint or robustness), kind of a stochastic edge removal problem.

  • determining whom and when to vaccine first (whenever they find it). Kind of a stochastic node blocking problem with some time index to minimize the expected number of infected people.

Recently i saw these links that contain some data


10

There is the following data set on the number of infections in China provided by Isaac Lin from the University of Hong Kong. https://github.com/BlankerL/DXY-COVID-19-Data/blob/master/README.en.md

I am not sure how reliable the data is, but it’s the best I could find. And from a first look, the numbers are close to what the German news are communicating. Isaac has created a web crawler which is also available on GitHub https://github.com/BlankerL/DXY-COVID-19-Crawler/blob/master/README.en.md

I was made aware of this data set when looking for visualizations of time trends and model predictions of confirmed cases on his website. E.g., https://ncov2020.org/en/en/predict-2020-03-05/


16

Actually, yes, and [email protected] is doing this right now.

https://foldingathome.org/2020/02/27/foldinghome-takes-up-the-fight-against-covid-19-2019-ncov/

We need your help! [email protected] is joining researchers around the world working to better understand the 2019 Coronavirus (2019-nCoV) to accelerate the open science effort to develop new life-saving therapies. By downloading [email protected], you can donate your unused computational resources to the [email protected] Consortium, where researchers working to advance our understanding of the structures of potential drug targets for 2019-nCoV that could aid in the design of new therapies. The data you help us generate will be quickly and openly disseminated as part of an open science collaboration of multiple laboratories around the world, giving researchers new tools that may unlock new opportunities for developing lifesaving drugs.

And another bit of info from the link:

One protein from 2019-nCoV, a protease encoded by the viral RNA, has already been crystallized. Although the 2019-nCoV spike protein of interest has not yet been resolved bound to ACE2, our objective is to use the homologous structure of the SARS-CoV spike protein to identify therapeutic antibody targets.


4

I cannot write regular comments, but the BOINC platform and their Rosetta team are fighting too:

https://www.ipd.uw.edu/2020/02/rosettas-role-in-fighting-coronavirus/

and

https://boinc.bakerlab.org/

The consortium consists of the University of Washington, Howard Hughes Medical Institute and Institute for Protein Design.

Feel free to add to the OP so others can help if they already use BOINC.


5

I'm not defining an optimization problem challenge, but providing a dataset I came across when visiting our world in data website. There is this data repository by Johns Hopkins Center for Systems Science and Engineering for COVID-19 cases. The data sources there are from World Health Organization (WHO) and the CDC of China, Hong Kong, US, Australia, Italy, Europe, and more.

Edit:

Amazon is making a public AWS COVID-19 data lake available.


4

Data about the COVID-19 cases in Italy is available on Github from the government:

https://github.com/pcm-dpc/COVID-19


8

We (operations research community in Italy) have just offered our availability to contribute as we can. On our web site https://webgol.dinfo.unifi.it we just starting collecting ideas on how to help. We think there is much that OR can do: assignment (we have strong imbalance between available beds and patients in acute care), transportation, ambulance scheduling, triage optimization, inventory management,....

Any help or suggestion from the community is more than welcome. My group also worked in the past on folding and molecular design, but I think in this moment our emergency is on the logistic side, there is no time, I guess, for a molecule. I mean, a vaccine would be very welcome, but I don't think we can wait, it's simply too late. Anyway, as we really do not know how long all of this will be, we just made available our computing resources and joined the [email protected] project https://foldingathome.org/ who is now devoted to finding potential drugs against the virus

Italy has taken impressive and very serious decisions to try to limit the spread; we hope other countries will follow the same path, the earlier the better for all.


7

Another optimization related problem (no data) is raised in the following recent article: How America Can Avoid Italy’s Ventilator Crisis.

The formulation of this ventilator distribution problem is the following:

Once industry rapidly scales ventilator production, where should these ventilators be delivered? Which hospitals need them most? How can we build a nimble logistics operation that can rapidly deploy these machines the moment that a shortage appears imminent?


3

My research group at MIT has collated a dataset of 130+ papers on COVID-19 clinical outcomes, where each paper contains aggregate demographic information/comorbidities/lab data/treatment/clinical outcomes on a group of patients http://www.covidanalytics.io/dataset.

Since we ultimately want to make decisions to combat the spread of COVID, we're currently in the process of using this data and an epidemiological model predicting COVID's spread to define and solve some optimization problems; I'll update this answer with some more details once we finalize these models and make them public.

We'd love to hear if anyone has suggestions for other optimization problems we can solve with this data.


1

We've recently been working on hospital staff rostering with covid-19 specific constraints, such as these:

enter image description here

There's a working demo on this branch on github. It's open source in java.